Chromosomal abnormality, megaloblastosis, and arrested DNA synthesis in erythroleukaemia.
نویسندگان
چکیده
Chromosomal studies of bone-marrow cells have been reported on 30 patients with erythroleukaemia (Table I). Some of these reports give only meagre cytogenetic details, but there was an increased degree of polyploidy in at least 9 of the patients, significant aneuploidy in 12, and structural abnormalities in 11. Some patients showed more than one of these features, and only 8 patients had normal chromosomes. For several reasons these reports probably do not give a reliable estimate of the incidence of cytogenetic abnormality in erythroleukaemia, but they do indicate that structural changes, which are often associated with hypodiploid numbers, and polyploidy are prominent features of this leukaemia. The structural abnormalities included separate instances of chromosome breakage in different cells of untreated patients (Heath and Moloney, 1965; Weatherall and Walker, 1965; Jensen, 1966), and also the presence ofcytogenetically abnormal cell lines, the most notable being the ring chromosomes described in two patients (Di Grado, Mendes, and Schroeder, 1964; Jensen, 1966). We report a further patient with erythroleukaemia whose bone-marrow showed megaloblastoid features, chromosome structural aberrations, including a cell line with a ring chromosome, polyploidy, and an associated abnormality of DNA synthesis.
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ورودعنوان ژورنال:
- Journal of medical genetics
دوره 6 1 شماره
صفحات -
تاریخ انتشار 1969